Time to Diagnosis Among Patients with Eosinophilic Esophagitis in the United States

EoE diagnosis is frequently delayed due to symptom overlap with other conditions, but the real-world magnitude of diagnostic delays—and which symptom presentations are associated with the longest journeys to diagnosis—had not been characterized in a large US EoE registry with prospective data.

The TARGET-EGIDs registry was used to describe the time from first EoE-related symptom or complication to confirmed diagnosis across 915 newly diagnosed EoE patients, stratified by symptom type and prior GERD diagnosis, with Bristol Myers Squibb as a funding partner.

Documenting that patients wait an average of 1–5 years from symptom onset to EoE diagnosis—with the longest delays in GERD-misdiagnosed patients—creates the evidence base for early diagnosis advocacy and supports the regulatory and commercial case for novel EoE therapies by demonstrating the unmet need of delayed intervention.

EoE diagnostic delay characterization for early diagnosis advocacy and novel therapy commercial strategy, Real-world time-to-diagnosis evidence supporting regulatory unmet need arguments for EoE drug development, Symptom-to-diagnosis benchmarking for EoE disease awareness and prescriber education programs